Thiazides can cause: (DNB Dec 2009)
|A||Hypokalaemic metabolic alkalosis|
a. Thiazides are slowly acting diuretics.
b. Mechanism of action: Inhibit Na/ Cl symporter in early part of distal convoluted tubules.
c. There is natriuresis and this is accompanied by volume loss. Inhibition of reabsoption of sodium in DCT is accompanied by loss of potassium and hydrogen ions. This can cause metabiolic alkalosis.
d. Other adverse effect side are: hypokalemia, hypomagnsemia, hypercalcemia, hyperglyecemia, hyperlipidemia and hyperuricemia. Impotence can occur.