Thrombin activity is inhibited by(AIPG 2008)
|B||Heparin cofactor II|
a. Thrombin activity is inhibited by
a. Heparin cofactor II
b. Alpha-1 antitrypsin and
c. Antithrombin III
b. Direct thrombin inhibitors such as bivalirudin, lepirudin, and argatroban are a new class of anticoagulants.
c. The mechanism of action of these agents differs from heparin in that they directly inhibit the active site of thrombin, and they do not require an interaction with antithrombin III to produce their anticoagulant effect.
d. Furthermore, contrary to heparin, direct thrombin inhibitor agents inhibit only the activity of thrombin whereas heparin, through its activation of antithrombin III, indirectly inhibits factors IIa (thrombin),Xa, IXa, XIa and XIIa.