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Medicine

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Neurology

Question
9 out of 15
 

Thymoma is associated with: (AIPG 2011)



A Myasthenia gravis

B Hypergammaglobulinemia

C SLE

D Multiple sclerosis

Ans. A

Myasthenia gravis

Clinical syndrome associated with Thymomas

Characteristic Syndrome

Rare Syndrome (Other autoimmune Disorders)

1). Myasthenia Gravis (Most common)

2). Acquired Hypogammaglobulinemia (10%)

3). Pure Red Cell Aplasia

1). Connective Tissue Disorders (Rare)

a. Polymyositis

b. Dermatomyositis

c. Granulomatous myocarditis

d. SLE

e. Rheumatoid Arthritis

f. Scleroderma and Sjögren’s syndrome

2). Pemphigus

3). Pernicious Anemia (Rare)

4). Auto immune Thyroiditis and Grave's disease (Rare)

Extra Edge:

1). Thymoma is associated with Hypogammaglobulinemia and not with hypergammaglobulinemia

2). Myoid cells are present in thymoma

Immune status with Thymoma:

1). T-cell number & cell mediated immunity are usually intact

2). These patients are very deficient in circulating B lymphocytes & pre B cell in the bone marrow

3). Hypogammaglobulinemia usually occurs relatively late in adult life.

4). Bacterial infection & severe diarrhea usually reflect this antibody deficiency.

5). Frequently have eosinopenia

6). May develop Red cell (Erythroid) Aplasia.

Neurology Flashcard List

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