Autonomic Nervous Systems
Tiotropium is used for the treatment of which of the following? (AIIMS May 2010)
a. Semisynthetic Anticholinergic Drug derivatives are: Homatropine,
b. Atropine methonitrate, Hyoscine butyl bromide, Ipratropium bromide,
c. Tiotropium bromide.
Tiotropium bromide is a recently developed congener of ipratropium bromide which binds tightly to bronchial M1 / M3 muscarinic receptors producing long lasting bronchodilation. Binding to M2 receptors
is less tight conferring relative M1 / M3 selectivity. Like ipratropium it exhibited bronchial selectivity in action.
Inhaled ipratropium / tiotropium are the bronchodilators of choice in COPD. They produce slower response than inhaled sympathomimetics and are better suited for regular prophylactic use.