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Pharmacology

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Respiratory Systems

Question
31 out of 47
 

Tiotropium is used for the treatment of which of the following? (LQ)



A Ptyalism
B Asthma

C Urinary retention
D Ileus

Ans. B Asthma

a. Semisynthetic Anticholinergic Drug derivatives are: Homatropine,

b. Atropine methonitrate, Hyoscine butyl bromide, Ipratropium bromide,

c. Tiotropium bromide.

d. Tiotropium bromide is a recently developed congener of ipratropium bromide which binds tightly to bronchial M1 / M3 muscarinic receptors producing long lasting bronchodilation. Binding to M2 receptors is less tight conferring relative M1 / M3 selectivity. Like ipratropium it exhibited bronchial selectivity in action.

e. Inhaled ipratropium / tiotropium are the bronchodilators of choice in COPD. They produce slower response than inhaled sympathomimetics and are better suited for regular prophylactic use.

Respiratory Systems Flashcard List

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