Tolazoline is used in: (DNB Dec 2010)
|A||As a vasodilator before coronary catheterization|
|B||As a vasoconstrictor used in treatment of varices|
|C||As thrombin inhibitor in peripheral angiography|
|D||Antispasmodic during biliary spasm|
Tolazoline is an imidazoline type of non-selective alpha-receptor blocker.
a. Alpha blockade is modest & short lasting.
b. Direct vasodilator & cardiac stimulant
c. It is used in Peripheral vascular disease and pulmonary hypertension in newborn.
d. It is also stimulant of GIT – antagonized by atropine – Ach like effect.
e. Stimulates salivary, GIT secretions.
The related drug is phentolamine. It is used in variety of conditions – to relieve the psuedo-obstruction in GIT, clonidine withdrawal or male sexual dysfunction.
a. It is not a vasoconstrictor – cannot be used in varices – causes vasodilatation. (Option B).
b. It produces Ach like effects – thus it cannot be anti-spasmodiC. (Option D).
c. Considering its peripheral vasodilating properties its use in peripheral angiography can be chosen as an answer but it is not a thrombin inhibitor. (Option C).
d. However its use in coronary angiography is not excluded by reference – it stimulates heart & produces tachycardia – its use during coronary angiography seems to be doubtful. (Option A).
So option A is best answer after excluding Option B, C & D