Autonomic Nervous Systems
Tolazoline is used in: (DNB Dec 2010)
|A||As a vasodilator before coronary catheterization|
|B||As a vasoconstrictor used in treatment of varices|
|C||As thrombin inhibitor in peripheral angiography|
|D||Antispasmodic during biliary spasm|
Tolazoline is a imidazoline type of non-selective alpha receptor blocker.
- Alpha blockade is modest & short lasting.
- Direct vasodilator & cardiac stimulant
- It is used in Peripheral vascular disease and pulmonary hypertension in newborn.
- It is also stimulant of GIT – antagonized by atropine – Ach like effect.
- Stimulates salivary, GIT secretions.
The related drug is phentolamine. It is used in variety of conditions – to relieve the psudo-obstruction in GIT, clonidine withdrawal or male sexual dysfunction.
a. It is not a vasoconstrictor – cannot be used in varices – causes vasodilatation(option B).
b. It produces Ach like effects – thus it cannot be anti-spasmodic. (option D).
c. Considering its peripheral vasodilating properties its use in peripheral angiography can be chosen as an answer but it is not a thrombin inhibitor. .(option C).
d. However its use in coronary angiography is not excluded by reference – it stimulates heart & produces tachycardia – its use during coronary angiography seems to be doubtful (option A).
So option A is best answer after excluding Option B , C & D