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Pharmacology

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Autonomic Nervous Systems

Question
49 out of 75
 

Tolazoline is used in: (DNB Dec 2010)



A As a vasodilator before coronary catheterization

B As a vasoconstrictor used in treatment of varices

C As thrombin inhibitor in peripheral angiography

D Antispasmodic during biliary spasm

Ans. A As a vasodilator before coronary catheterization

Tolazoline is a imidazoline type of non-selective alpha receptor blocker.

  1. Alpha blockade is modest & short lasting.
  2. Direct vasodilator & cardiac stimulant
  3. It is used in Peripheral vascular disease and pulmonary hypertension in newborn.
  4. It is also stimulant of GIT – antagonized by atropine – Ach like effect.
  5. Stimulates salivary, GIT secretions.

The related drug is phentolamine. It is used in variety of conditions – to relieve the psudo-obstruction in GIT, clonidine withdrawal or male sexual dysfunction.

a. It is not a vasoconstrictor – cannot be used in varices – causes vasodilatation(option B).

b. It produces Ach like effects – thus it cannot be anti-spasmodic. (option D).

c. Considering its peripheral vasodilating properties its use in peripheral angiography can be chosen as an answer but it is not a thrombin inhibitor. .(option C).

d. However its use in coronary angiography is not excluded by reference – it stimulates heart & produces tachycardia – its use during coronary angiography seems to be doubtful (option A).

So option A is best answer after excluding Option B , C & D

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