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Medicine

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Hematology

Question
15 out of 15
 

Treatment of PNH is (PNQ)



A Eculizumab
B Infliximab

C Rituximab
D Alemtuzimab

Ans. A

Eculizumab

Recent Advances: New Drug Eculizumab:

Eculizumab is a monoclonal antibody that specifically binds to the complement protein C5, thus inhibiting terminal complement mediated intravascular hemolysis in PNH patients.

It is also useful in rheumatoid arthritis and other chronic inflammatory diseases, e.g. nephritis.

Extra Edge: (Ref. Hari- 18th ed., page 88)

The only form of treatment that currently can provide a definitive cure for PNH is allogeneic bone marrow transplantation (BMT). When an HLA-identical sibling is available, BMT should be offered to any young patient with severe PNH; the availability of eculizumab has probably decreased significantly the proportion of those who take up this option.

Hematology Flashcard List

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