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  1. Tuberous Sclerosis (Epiloia):
    1. It is an autosomal dominant disorder of multisystem hamartomatosis characterized by classic triad of seizures (epilepsy), mental retardation (low intelligence) and adenoma sebaceum.
    2. Netherton’s syndrome:
    3. It is a rare autosomal recessive genodermatosis characterized by triad of congenital ichthyosiform erythroderma (later ichthyosis linearis circumflexa may develop), trichorrhexis invaginata (bamboo hair), and atopic diathesis with failure to thrive.
  2. Dyskeratosis Congenita (Zinsser–Cole–Engman Syndrome):
    This is a multisystem ectodermal dysplasia, in which a triad of cutaneous abnormalities are the most consistent and diagnostic feature, comprising reticulate hyperpigmentation of the skin, nail dystrophy (longitudinal ridging, splitting and early pterygium formation) and leukokeratosis of mucous membranes. Aplastic anaemia occurs in 50% of patients. Dental, skeletal, ocular and gastrointestinal abnormalities; mental retardation, short stature and premature ageing also occur. Most cases have X-linked recessive inheritance.
  3. Wiskott-Aldrich Syndrome:
    It is a X-linked recessive immunodeficiency disorder characterized by the classic triad of atopic-like dermatitis, a bleeding tendency due to microthrombocytopenia, and recurrent sinopulmonary infections.[34]
  4. Hermansky–Pudlak Syndrome:
    It is an autosomal recessive disorder of melanosome biogenesis presenting with a triad of oculocutaneous albinism, hemorrhagic diathesis due to absence of dense bodies in platelets and deposition of ceroid-like material in within lysosomes in affected internal organs, including the lungs and gastrointestinal tract.[36]
  5. Birt–Hogg–Dubé Syndrome:
    This syndrome is an autosomal dominant genodermatosis characterised by classic triad of multiple trichodiscomas, trichofolliculomas and acrochordon-like lesions.
  6. Neoplasm:
    1. Sézary syndrome:
      It is defined as the presence of a clinical triad consisting of generalized exfoliative erythroderma, peripheral lymphadenopathy and atypical mononuclear cells (Sézary cells) comprising 5% or more of peripheral blood lymphocytes on a buffy coat smear, or more than 20% of total lymphocyte count or a total Sézary count of more than 1000 ×109/L .
  7. Hand–Schüller–Christian Disease:
    It is a type of langerhans cell histiocytosis characterised by triad of diabetes insipidus, bone lesions and exophthalmos.

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