True about Nelson syndrome? (LQ)
|A||Very high serum ACTH|
|B||Pituitary surgery is done|
|C||Very aggressive pituitary gland|
|D||All are true|
All are true
1). It is the rapid enlargement of apituitary adenoma that occurs after the removal of both adrenal glands.
2). Most aggressive growing pituitary tumor.
3). Removal of both adrenals eliminates production of cortisol, and the lack of cortisol ‘s negative feedback can allow any preexisting pituitary adenoma to grow unchecked.
4). Continued growth can cause mass effects due to physical compression of brain tissue, along with increased production of ACTH and MSH.
5). Very high serum ACTH (> 100 micro gram/ml) causing hyperpigmentation and due to mass effect causes headache. It can invade cavernous sinus.
6). Treatment of Nelson Syndrome: Pituitary surgery is performed in some cases. The risk can also be minimized by pituitary irradiation.