True about Octrecotide: (DNB Dec 2009)
|A||Is active orally|
|B||Is not a somatostatin analogue|
|C||Used in secretory diarrhea|
|D||Is a growth hormone agonist|
- Octreotoide is a synthetic octapeptide with actions similar to somatostatin.
- Routes of administration:
- Intravenous (v. short duration of action)
- Intramuscular (depot preparation)
- It is 40 times more potent than somatostatin in suppressing GH secretion.
- It is being preferred over somatostain for acromegaly and secretory diarrheas associated with carcinoid, AIDS, cancer chemotherapy or diabetes.
Based on properties of inhibiting secretion of various hormones (GH, TSH, PL, insulin, glucagon), all GI secretions (including gastrin & HCI) and constriction of splanchnic, hepatic and renal blood vessels.
a. Carcinoid and VIPoma induced secretory diarrhea and systemic symptoms such as flushing and wheezing.
b. Diarrhea due to vagotomy and dumping syndrome, short bowel syndrome or AIDS.
c. GI bleeding
d. Pancreatic fistula, insulinoma, glucagonoma, pancreatic ascites
e. Oncogenic osteomalacia
Adverse effects: Abdominal pain, nausea, steatorrhoea, diarrhea, gallstones.