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Medicine

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Hematology

Question
4 out of 8
 

True about Sideroblastic anemia?



A X-link
B Mitochondrial

C Autosomal dominant
D All of the above

Ans. D

All of the above

1. Laboratory findings of sideroblastic anemia

a. Increased ferritin levels

b. Decreases total iron-binding capacity

c. Hematocrit of about 20-30%

d. Serum Iron: High

e. High transferrin saturation

f. MCV is usually normal or low

g. Stainable BM hemosiderin is increased.

2. Diagnosis.

a. Older than 60 years levels of 8-10 g/dl.

b. Normocytic or even macrocytic and dimorphous population with some very small cell.

c. Iron staining demonstrates the ringed sideroblasts.

d. Iron studies show elevated ferritin levels and normal or high serum iron levels with high transferrin saturation.

3. Therapy.

a. Pyridoxine in high does; however, in all but the hereditary cases, this usually fails.

b. Often, these patients have transfusion depended diseases.

c. Exogenous erythropoietin.

Extra Edge:

Lab Parameter

IDA

Thalassemia

Sideroblastic

AOCD

S. Fe

N

N

TIBC

N

N or

S ferritin

<15

(50-300)

(50-300)

N or

Hb electrophoresis

N

Abnormal

N

N

Free erythrocyte protoporphyrin

N

* AOCD – Anemia of Chronic Disease.