True about carbamazepine?
|A||Can cause megaloblastic anemia|
|B||Levels are decreased by erythromycin|
|C||Can be used in treatment of trigeminal neuralgia|
|D||Hyponatremia is common with its longterm use|
(Ref. KDT Pharmacology 6th ed. pg. 405, 578, 816; , Harrison's Principles of Internal Medicine 16th Edition pg. 2368t, 2435)
Carbamazepine Is Used –
a. for seizures (Tonic-clonic, Focal-onset), b. for pain,
c. for trigeminal neuralgia d. for glossopharyngeal neuralgia,
e. for diabetic neuropathy, f. for bipolar disorder,
g. for mood disorders, h. for stress disorders,
i. for brain tumor, j. for Fabry disease,
k. for hypernatremia, l. for cramps,
Importantly, carbamazepine is a mood stabilizer and is an iminostilbine derivative. The drug is well absorbed orally and undergoes autoinduction (that means, half life will undergo changes upon chronic administration). It is the drug of choice for partial seizures.