Thyroid & Adrenal
True about carotid body tumor is all, except:
|B||Secretes catecholamines invariably|
|C||Surgery is the only treatment|
|D||Non-chromaffin in origin.|
a. Carotid body tumors (CBTs) are rare neoplasms, although they represent about 65% of head and neck paragangliomas. These tumors develop within the adventitia of the medial aspect of the carotid bifurcation.
b. The carotid body, which originates in the neural crest, is important in the body's acute adaptation to fluctuating concentrations of oxygen, carbon dioxide, and pH. The carotid body protects the organs from hypoxic damage by releasing neurotransmitters that increase the ventilatory rate when stimulated.
c. Carotid body tumors (CBTs) constitute about 65% of head and neck paragangliomas.
d. Carotid body tumors (CBTs) can occur in children; however, carotid body tumors (CBTs) are considered to be a disease of middle age. The mean age of onset is reported to be 45 years.
e. Paragangliomas are inherited in 10-50% of cases.
f. Age of onset in the hereditary group is typically younger, in the second to fourth decade.
g. About 5% of carotid body tumors (CBTs) are bilateral and 5-10% are malignant, but these rates are much higher in patients with inherited disease.
h. Familial tumors are found to be 5.8 times more common among patients who have carotid body tumors as compared with patients who have paragangliomas at other sites.
i. The only known risk factors are the presence of chronic hypoxic stimulation and the genetic predisposition.
j. Vagal body tumors are more cranially located and sometimes project into the lateral pharynx as a pulsatile mass
k. MRI imaging is considered to be the criterion standard of carotid body tumors, and the tumor has a characteristic salt and pepper appearance on T1-weighted image.