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Medicine

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Kidney

Question
10 out of 14
 

True about hyperoxaluria? (AIIMS Nov 06)



A Autosomal recessive

B Can occur in Crohn’s Disease

C Can occur in short bowel syndrome

D All of the above

Ans. D All of the above

Hyperoxaluria

i. Primary hyperoxaluriais an autosomal recessive inherited metabolism due to an enzyme defect.

ii. Secondary hyperoxaluriais due to intake eg rhubarb, spinach, tea, intestinal reabsorption due to ileal disease (Crohn’s, ileal bypass), short bowel syndrome, low Ca2+ intake.

iii. Signs: Oxalate renal stones nephrocalcinosis, progressive renal failure, cardiac conduction defect arterial disease (oxalate crystallization), osteodystrophy.

iv. Treatment

a. High fluid intake to prevent calculi (keep urine output 3L day), reduced dietary oxalate, calcium supplements (binds oxalate in the gut so reduces absorption).

b. If these do not work, pyridoxine (vitamin B6) is given to reduce endogenous oxalate production

(Side Effect: pyridoxine in high doses can cause peripheral neuropathy !!!).

c. Magnesium or cholestyramine are also used to decreased oxalate absorption.

d. Hepatic transplantation may be curative in primary hyperoxaluria, and may be combined with renal transplant.

Kidney Flashcard List

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