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Physiology

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Kidney

Question
17 out of 19
 

True about nephron is (DNB June-2009)



A Na is absorbed actively in descending loop of Henle

B 60 to 70% of GFR is absorbed in proximal tubule

C Absorption of water occurs in ascending loop of Henle

D The filtrate reaching distal convoluted tubule is hypertonic with respect to surroundings

Ans. B 60 to 70% of GFR is absorbed in proximal tubule

I. The Proximal tubules reabsorbes 60% to 65% of the filtered NaQ+, Cl--, HCO3-Q and waterQ, and virtually all the filtered K+ HPO42- and amino acid Q

II. Segments of nephrons which are impermeable to water: ­ Q

Ascending loop of Henle (but permeable to Na+ and Cl-)Q

Early DCTrelatively impermeable to water. Q

III. Hormones that regulate Tubular reabsorption: ­

Hormones

Site of action

Effects

- Aldosterone

Late Distal tubule and collecting duct Q

NaCl, H2O reabsorption

K+ secretion

- ADH (vasopressin)

Late distal tubule and collecting duct Q

H2O reabsorption

  1. Late distal tubule and cortical collecting tubule: -

a. They are composed of two distinct cells - Principal cells and Intercalated cells

b. The principal cells reabsorb Na+ and H2O; and secrete K+

c. Intercalated cells reabsorb K+ and HCO3- and; secrete H+ (ie. Acid base balance)

  1. Summary of the changes in the osmolality of tubular fluid invarious parts of the' nephron: ­

a. PCT Isotonic Q

b. Loop of HenleHypertonic Q

c. Ascending limb of loop HenleHypotonic (less)Q

d. DCT Hypotonic (more)Q

e. Collecting duct Hypertonic Q

  1. Na + reabsorption: - "In the PCT, thick portion of the Ascending limb of loop of Henle, DCT, and collecting duct, Na+ moves by co-transport

Kidney Flashcard List

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