True about neuroblastoma is (AIIMS May 2013)
|A||Most Common intra-abdominal solid tumor in children|
|B||Most common site is adrenals|
|C||In Spinal cord presents as Dumb-bell tumour|
|D||All of the above|
All of the above
a. Most Common intra-abdominal solid tumor in children.
b. It is tumour of Autonomic nervous system arising from Neural crest.
c. 50% present at < 2 years, 90% present at < 6 years.
2. Etiology: not known
3. Clinical Features: Are related to localization and metastasis.
a. Most common site is adrenals (30%).
b. Paravertebral retroperitoneum (28%).
c. Can occur in Sympathetic chain anywhere from neck to pelvis.
d. Can present as-Asymptomatic mass: Intra thoracic, retroperitoneal, Abdominal.
e. Symptomatic - Diarrhea, HT, Sweating, emaciated with metastasis.
f. In Spinal cord as Dumb-bell tumour→paraplegia.
g. Metastasis to Bone - facial and skull (60-70%), Opsoclonus (dancing eyes).
Stages: Stage I: Tumour confined to organ of origin.
Stage II: Extend beyond organ of origin but do not cross midline.
Stage III: Tumour crosses midline.
Stage IV: Disseminated to distant sites: Bone, bone marrow, distant LN, other organs.