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Paediatric

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Malignancies

Question
38 out of 61
 

True about neuroblastoma is (AIIMS May 2013)



A Most Common intra-abdominal solid tumor in children

B Most common site is adrenals

C In Spinal cord presents as Dumb-bell tumour

D All of the above

Ans. D

All of the above

1. Neuroblastoma

a. Most Common intra-abdominal solid tumor in children.

b. It is tumour of Autonomic nervous system arising from Neural crest.

c. 50% present at < 2 years, 90% present at < 6 years.

2. Etiology: not known

3. Clinical Features: Are related to localization and metastasis.

a. Most common site is adrenals (30%).

b. Paravertebral retroperitoneum (28%).

c. Can occur in Sympathetic chain anywhere from neck to pelvis.

d. Can present as-Asymptomatic mass: Intra thoracic, retroperitoneal, Abdominal.

e. Symptomatic - Diarrhea, HT, Sweating, emaciated with metastasis.

f. In Spinal cord as Dumb-bell tumourparaplegia.

g. Metastasis to Bone - facial and skull (60-70%), Opsoclonus (dancing eyes).

Extra Edge:Neuroblastoma

Stages: Stage I: Tumour confined to organ of origin.

Stage II: Extend beyond organ of origin but do not cross midline.

Stage III: Tumour crosses midline.

Stage IV: Disseminated to distant sites: Bone, bone marrow, distant LN, other organs.

Malignancies Flashcard List

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