True about primary pulmonary hypoventilation is: (AIIMS May 2009)
|A||Does not respond to chemical stimuli|
|B||Hypocapnia and normal PaO2|
|C||Common in children|
|D||Respiratory alkalosis is diagnostic|
Does not respond to chemical stimuli
Primary pulmonary hypoventilation
1). Impaired chemoreception resulting in decreased ventilatory drive.
2). Chronic hypercapnia and hypoxemia in the absence of identifiable neuromuscular disease or mechanical ventilatory impairment.
1). Mostly in males aged 20-50 years.
2). Early: lethargy, fatigue, daytime somnolence, disturbed sleep and morning headache.
3). Late: Cyanosis polycythemia, pulmonary hypertension, congestive heart failure.
Extra Edge: Dyspnea is uncommon despite severe arterial blood gas derangements
The key diagnostic feature is respiratory acidosis in the absence of respiratory muscle weaknesses or impaired ventilatory mechanics.
1). Bronchodilators such as beta-agonists, anticholinergic agents, and methylxanthines are helpful in treating patients with obstructive lung disease and severe bronchospasm.
2). Treatment also is aimed at assisting ventilation