72 out of 75
True about protease inhibitors are all except:
|A||Acts as a substrate for P-glycoprotein (P-gp) and action is mediated by MDR-1 gene|
|C||All protease inhibitors interfere with metabolism by drug interactions|
|D||Saquinavir causes maximum induction of CYP3A4|
Ans. D Saquinavir causes maximum induction of CYP3A4
Squinavir is an enzyme inhibitor like all protease inhibitors.Squinavir is least potent enzyme inhibitor. Ritonavir is most potent enzyme inhibitor.