10 out of 75
True about protease inhibitors are all except:
|A||Acts as a substrate for P-glycoprotein (P-gp) and action is mediated by MDR-1 gene|
|C||All protease inhibitors interfere with metabolism by drug interactions|
|D||Saquinavir causes maximum induction of CYP3A4|
Ans. D Saquinavir causes maximum induction of CYP3A4
Squinavir is an enzyme inhibitor like all protease inhibitors. Ritonavir is most potent enz inhibitor. That is why it is given with Squinavirto increase its metabolism ….