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Medicine

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Liver & GIT

Question
7 out of 9
 

True about trientine is all except (AIPG 2010)



A Anemia caused by it can be treated with short term iron

B Should be separated from iron for at least 2 hrs

C More potent than penicillamine

D Used in Wilson’s whocan not tolerate penicillamine

Ans. A Anemia caused by it can be treated with short term iron

Role of Trientine

1. Trientine act by chelation or binding of copper, causing its increased urinary excretion.
2. Trientine is indicated especially in patients who are intolerant to D-penicillamine or have clinical feature indicating potential intolerant to D-penicillamine.

3. Trientine has fewer side effects in comparison to D-penicillamine and worsening of neurological symptoms after beginning of treatment appears much less common than with D-penicillamine.

Trientine Side Effects

Most common – anemia (It needs long term treatment for its correction)

Rare

i. Fever

ii. General feeling of discomfort, illness, or weakness

iii. Joint pain

iv. Skin rash, blisters, hives, or itching

v. Swollen glands

Note: Signs of anemia are more likely to occur in children, menstruating women, and pregnant women, who usually need more iron than other patients.

Liver & GIT Flashcard List

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