True about Benzodiazepines as compared to other hypnotics
|A||They alter sleep pattern more than other hypnbotics|
|B||More sedative than other hypnotics|
|C||Overdose is better tolerated compared to other hypnotics|
|D||All of above|
a. Ref Good man Gillman 11th edition, KDT 5th edition Page no. 362 "Benzodiazepines act on GABA" but not GABAB receptors by binding directly to a specific site that is distinct from that of GABA" binding" (Page No. 405 Goodman Gilman 11th edition.)
b. Unlike barbiturates, benzodiazepines (BZD. do not activate GABAA receptors directly but they only modulate the effects of GABA.
c. BZDs partially protect against stress ulcers in rats, and diazepam markedly decreases nocturnal gastric secretion in human beings. Other agents are considerably more effective in acid - peptic disorders'
d. (Page 407 Goodman & Gilman 11th edition.)
e. The BZDs are metabolized extensively by cytochrome P450 enzymes, particularly CYP3A4 and CYP2C19. (Page 408 Goodman & Gilman 11th edition.)
f. They have active metabolites.