Gram Negative Bacilli
True for Vi polysaccharide vaccine
|A||Local side effects are common|
|B||Severe systemic side effect|
|C||Contra indicated in HIV|
|D||Can be given with other vaccine like Hep B & Yellow fever|
Can be given with other vaccines
a. Typhim Vi is a subunit vaccine containing the cell surface Vi polysaccharide extracted from Salmonella enterica serovar Typhi, S typhi Ty2 strain. Typhim Vi vaccine is indicated for active immunization against typhoid fever for persons two years of age or older. The antibody response may be inadequate in children under 2 years of age.
b. Immunization with Typhim Vi vaccine should occur at least two weeks prior to expected exposure to S typhi. Dose for adults and children is a single injection of 0.5 mL given intramuscularly in the deltoid. Reimmunization every two years under conditions of repeated or continued exposure to the S typhi organism is recommended at this time.
c. Typhim Vi vaccine has efficacy against typhoid fever caused by S typhi infection The adverse reactions are predominately minor and transient local reactions.
d. Local reactions such as injection site pain, erythema and induration almost always resolve within 48 hours of vaccination.
e. Though the antibody response in immunodeficiency states are often suboptimal, it should be given in HIV patients. TYPHIM Vi may be administered during the same vaccination session with other common vaccines (yellow fever, diphtheria, tetanus, poliomyelitis, rabies prepared on Vero cells, meningitis A+C, hepatitis A and hepatitis B
f. Other vaccines for prophylaxis against enteric fever are mono/di/trivalent heat- killed phenol preserved parenteral vaccines and live attenuated Typhoral vaccine which is a Gal E mutant strain of S. typhi2 1a administered orally.