True regarding Sjogren's syndrome are all of the following except:
|B||Males are commonly affected|
|C||Progressive destruction of lacrimal and salivary gland|
|D||No single laboratory investigation is pathognomonic|
• Chronic disease characterized by dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia) resulting from immunologically mediated destruction of the lacrimal and salivary glands,
• It occurs as an isolated disorder (primary form), also known as the sicca syndrome or more often in association with another autoimmune disease (secondary form)
• Rheumatoid arthritis is the MC associated disorder
• Characterized by lymphocytic infiltration and fibrosis of the lacrimal and salivary glands".
• Earliest histologic finding in both the major and minor salivary glands is periductal and perivascular lymphocytic infiltration.
a. Most important antibodies: Directed against SS-A (Ro) and SS-B (La), which can be detected in 90% of patients (serologic markers? of the disease)
b. Patients with high titers of antibodies to SS-A are more likely to have early disease onset, longer disease duration, and extraglandular manifestations.
• Occurs most commonly in women between the ages of 50 and 60.
• Characteristic symptoms: Keratoconjunctivitis and xerostomia
• Parotid gland enlargement is present in half of the patients?
• Extraglandular disease are seen in one third of patients
• Biopsy of the lip (to examine minor salivary glands) is essential for the diagnosis of Sjögren syndromes,