Autocoids (Histamine and Serotonin)
True stagements regarding aspirin toxicity are (PGI Nov 2010)
|A||Tinnitus is an early symptom|
|B||10-30 g causes poisoning|
|C||Hyperthermia, tachypnea are early complications|
|D||Cause thrombocytopenic purpura|
|E||Children can tolerate much higher dose than adults|
Symptoms of aspirin poisoning
At anti-inflammatory dose (3-6 gm/day) produces the syndrome called Salicylism comprising of dizziness, tinnitus,
vertigo, excitement, mental confusion, reversible impairment of hearing.
The dose has to be titrated to one, which is just below that produces these symptoms, tinnitus is a good guide.
Metabolic acidosis, hyperthermia and acidotic breathing are seen in severe poisoning
Aspirin causes platelet dysfunction by inhibiting cydooxygenase pathway.
Fatal dose in adult is 15-30 g but considerably lower in children.