Autocoids (Histamine and Serotonin)
True statement about cyclooxygenase -2 is
|A||It is not inhibited by indomethacin|
|B||It is inducible|
|C||It generates cytoprotective prostaglandins in gastric mucosa|
|D||It is found only in fetal tissues|
COX-l is a housekeeping enzyme that is responsible for the generation of gastroprotective PGs. COX-2 is an inducible enzyme whose production is markedly increased at inflammatory sites. Indomethacin is a non-selective inhibitor of both isoforms of COX.