Autocoids (Histamine and Serotonin)
True statements about TXA2 is (PGI JUNE, 2006)
|A||It is formed in platelets|
|B||It is formed from PGG/H2|
|C||It is prothrombotic|
|D||It is having platelet anti-aggregatory activity|
|E||Aspirin can inhibit its production|
•TXA2 is produced inside the platelets with the help of TXA2 synthetase.
•It is formed from cyclic endoperoxides (PGG/H2) with the help of an enzyme, cyclooxygenase.
•Aspirin inhibits its production by irreversible inhibition of cyclooxygenase enzyme.
•TXA2 causes aggregation of platelets, therefore is prothrombotic.