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Biochemistry

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Amino Acids, Proteins and Porphyrins

Question
34 out of 36
 

Trypsin can be activated by which of the following?(AIPG 2008)



A Alpha-I antitrypsin
B Alpha-I-anti proteinase

C Enterokinase
D Egg-white

Ans. C Enterokinase

Explanation

a. Trypsin is a proteinase.

b. It can hydrolyze a peptide bond formed by the carbonyl group of a lysine residue on trypsinogen, converting the latter to trypsin and inactive Hexa peptide.

c. It can be activated (i.e., trypsinogen converted to trypsin)by enterokinase

d. The powerful protein-splitting enzymes of the pancreatic juice are secreted as inactive proenzymes.

e. Trypsinogen is converted to the active enzyme trypsin by the brush border enzyme enteropeptidase (enterokinase)when the pancreatic juice enters the duodenum.

a. Enteropeptidase contains 41 %polysaccharide, and this high polysaccharide content apparently prevents it from being digested itself before it can exert its effect.

Type of LP Lipids Risk of Treatment disorder increased elevated atherosclerosis

1G CH

I CM +++ N No None

IIa LDL N +++++ Statins

IIb VLDL and LDL +++++++ Statins, fibrates, nicotinic acid

III IDL and CMR ++++++ Fibrates

IV VLDL ++N ++ Fibrates, nicotinic acid

a. V VLDL and CM ++N No None

b. Trypsin converts chymotrypsinogen into chymotrypsin’s and other pro enzymes into active enzymes.

c. Trypsin can also activate trypsinogen; therefore, once some trypsin is formed, there is an autocatalytic chain reaction.

d. Enteropeptidase deficiency occurs as a congenital abnormality and leads to protein malnutrition.

e. Alpha -I Anti trypsin is the principal serine protease inhibitor of human plasma. It inhibits trypsin, elastase and certain other proteases forming complexes with them.

f. Alpha-I-anti proteinase is the new name for alpha – I Anti trypsin

g. Enterokinase activates trypsinogen into trypsin in the presence of Calcium

h. Egg-white is a trypsin inhibitor

i. Other trypsin inhibitors are:

a. Human and bovin Colostrum

b. Raw Soybeans

c. DFP (Di Iso propyl fluoro phosphate)

Amino Acids, Proteins and Porphyrins Flashcard List

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