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Medicine

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Neurology

Question
5 out of 14
 

Tumor with best prognosis is: (AIIMS May 2011)



A Ependymoma
B Medulloblastoma

C Cerebellar astrocytoma
D Glioblastoma multi forme

Ans. C

Cerebellar astrocytoma

Cerebellar Astrocytomas

1). Cerebellar Astrocytomas are equally common in both males & females.

2). The predominant group of astrocytomas in childhood are low grade astrocytomas (Nelsons)

3). Juvenile Pilocytic Astrocytoma (JPA) is the most common astrocytoma in children

4). Juvenile Pilocytic Astrocytoma is a low grade tumor and is classified as a WHO grade I tumor

5). Cerebellar Astrocytomas (Juvenile JPA) most commonly develop during the first two decades of life (WHO classification of Tumors of CNS)

6). Cerebellar Astrocytomas have a very good prognosis

7). With complete surgical resection the overall survival for Juvenile Pilocytic Astrocytomas approaches 80% - 100%


Astrocytomas

Non infiltrating (low grade) Benign : WHO grade I

1). Pilocytic astrocytoma

2). Pleomorphic xanthoastrocytoma

3). Sub ependymal giant cell astrocytoma

Infiltrating WHO Grade II, III, IV

1). Low grade astrocytomas (WHO Grade II)

a. Fibrillary

b. Gemistocytic

c. Protoplasmic

2). High Grade (WHO Grade III/IV)

a. Anaplastic Astrocytoma (WHO III)

b. Glioblastoma Multiforme (WHO IV)


Important points

1). Astrocytoma (Cerebellar)

a. Most common posterior fossa tumor in children is Cerebellar Astrocytoma

b. Most common brain tumor in children is also Cerebellar Astrocytoma.

c. Astrocytoma also has the best prognosis in children.

d. Tumor with best prognosis in children is also Astrocytoma.

2). Medulloblastoma

a. The second most common posterior fossa tumor in children.

b. Tumor which spreads along CSF pathways is medulloblastoma.

c. Tumor which is capable of metastasizing to extracranial sites is medulloblastoma.

d. Medulloblastoma is highly radiosensitive.

3). Brain Stem Gliomas:

These are the third most frequent post fossa tumors in children

4). Craniopharyngioma:

These are the most common supratentorial tumor in children.

Neurology Flashcard List

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