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Pharmacology

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Blood

Question
10 out of 45
 

Twenty months after finishing her chemotherapy, the woman had a relapse of breast cancer. The cancer was now unresponsive to standard doses of chemotherapy. The decision was made to treat the patient with high-dose chemotherapy followed by autologous stem cell transplantation. Which of the following drugs is most likely to be used to mobilize the peripheral blood stem cells needed for the patient's autologous stem cell transplantation? (LQ)



A Erythropoietin

B Filgrastim (G-CSF)

C Folic acid

D Intrinsic factor

E Oprelvekin (interleukin-II)

Ans. B Filgrastim (G-CSF)
  1. The success of transplantation with peripheral blood stem cells depends on infusion of adequate numbers of hematopoietic stem cells.
  2. Administration of G-CSF to the donor (in the case of autologous transplantation, the patient who also will be the recipient of the transplantation) greatly increases the number of hematopoietic stem cells harvested from the donor's blood and available for the transplantation procedure.

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