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Pathology

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Genetics

Question
2 out of 7
 

Two siblings with Osteogenesis imperfecta, but their parents are normal. Mechanism of inheritance is explained by: (AIPG 2012)



A Anticipation
B Genoming imprinting

C Germ line mosaicism
D New mutation

Ans. C Germ line mosaicism

In some autosomal dominant disorders, exemplified by osteogenesis imperfecta, phenotypically normal parents have more than one affected child.