Untreated diabetes lead to
|A||Tissue use fatty acids as main fuel|
|B||Inhibition of gluconeogenesis & stimulation of glycolysis|
|C||Insulation of breakdown of triacylglycerol|
|D||Storage of glucose as glycogen|
Metabolic abnormities in Insulin dependent Diabetes: -
(very similar to that observed during starvation)
a. Glucose uptake by tissue is impaired.
b. Glycolysis is depressed
c. Gluconeogenesis is stimulated
d. Lipolysis of triacylglycerol is stimulated
e. Synthesis of fatty acid (Lipogenesis) and triacylglycerol is depressed.
f. Fatty acid oxidation is increased.
g. Glycogen stores are depleted.
h. Ketone-bodies are synthesized in the liver and used as fuel by other tissues
i. Proteins are degraded and the amino-acids are used as fuel.
j. The level of the glucose, fatty acids, and ketone bodies in the blood become very high
k. Excess glucose leads to glycosylation of Hb and possibly other proteins.