Amino Acids, Proteins and Porphyrins
Urea is formed In
a. Urea is synthesized in Liver and clear by kidney: urea is the major end product of N2 catabolism of human –
b. Although brain tissues can form urea, but major mechanism for detoxification of NH3 is glutamine
c. The urea cycle occurs exclusively in the Liver
d. Kidney - Urea cycle operates in limited extend: - Kidney can form up to arginine but cannot form urea as enzyme Arginase is absent in kidney.
e. Brain —can synthesize urea from citrulline but lacks enzymes for forming citrulline from ornithine