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VOGT – Koyanagi Harada Syndrome

  • Idiopathic, multisystem disorder which typically affects pigmented individuals
  1. HLA – DR4 associated
  2. Skin / Neuro / Ocular
  3. Alopecia / Vitiligo / Poliosis
  4. Deafness / Meningismus
  5. Siguras sign/ sunset fundus
  6. Chr. Granulomatous Panuveities
  7. Multiple serous RD
  1. Skin and Hair changes
    1. Alopecia
    2. Poliosis
    3. Vitiligo (Sugiura’s sign*) – Perilimbal vitiligo*
  2. Neurological Features
    1. Encephalopathy
    2. Auditory symptoms – tinnitus vertigo, deafness
    3. CSF – lymphocytosis
  3. Ocular Features-
    1. Chronic granulomatous iridocyclitis

Multifocal choroiditis – Orange sunset fundus*
                          
↓  

Multifocal detachment of sensory retina





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