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Physiology

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Kidney

Question
11 out of 26
 

Vasopressin secretion is increased by



A Decreased ECF volume

B Carbamazepine

C Option A, B is right

D Procainamide

Ans. C Decreased ECF volume, Carbamazepine

VASOPRESSIN

i. It hormone of the posterior pituitary gland, and is synthesized in the cell bodies of the magnocellular neurons in the supra-optic and paraventricular nuclei of hypothalamus.

  1. Because one of its principal physiologic effects is the retention of water by the kidney, vasopressin is often called the ADH. i.e. the conc. of urine and the osmolality of the plasma.
  2. Its deficiency cause — Diabetes insidipus i.e. polyuria ( = the conc. of urine, Hypotonic urine) and es the osmolality of plasma.
  3. Summary of stimuli affecting vasopressin secretion:

Vasopressin secretion increased

Vasopressin secretion decreased Q

1. Increased effective osmotic pressure of plasma Q

2. Decreased ECF volume Q

3. Pain, Emotion, “stress”, exercise Q

4. Nausea, vomitting, standing Q

5. Clofibrate, carbamazepine, Angiotensin II Q

1. Decreased effective osmotic pressure of plasma

2. Increased ECF volume

3. Alcohol Q

a. Drugs ed vasopressin secretion (SIADH): - chiorpropamide, vincristine, vincristine, cyclophosphamide, carbamazepine, oxytocin, GA, Narcotics, TAD.

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