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Biochemistry

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Vitamins, Harmones and Hemoglobin

Question
16 out of 30
 

Vit K dependent clotting factor (AIPG 2010)



A Factors V & VIII

B Factors XI & XIII

C Factors IX and X

D Factors III + XI

Ans. C Factors IX and X

a. Vitamin K is involved in the carboxylation of certain glutamate residues in proteins to form gamma-carboxyglutamate residues (abbreviated Gla-residues).

b. The modified residues are often (but not always) situated within specific protein domains called Gla domains. Gla-residues are usually involved in binding calcium.

c. The Gla-residues are essential for the biological activity of all known Gla-proteins.

d. Till date 14 human proteins with Gla domains have been discovered, and they play key roles in the regulation of three physiological processes:

e. Blood coagulation: (prothrombin (factor II), factors VII, IX, X, protein C, protein S, and protein Z)

f. Bone metabolism: osteocalcin, also called bone Gla-protein (BGP), and matrix Gla protein (MGP).

g. Vascular biology

Vitamins, Harmones and Hemoglobin Flashcard List

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