We prescribe bromocriptine for a woman with primary amenorrhea. Normal menstruation returns about a month after starting therapy. The drug worked by doing which of the following? (AIPG 2012)
|A||Blocking estrogen receptors, enhancing gonadotropin release.|
|B||Increasing follicle-stimulating hormone (FSH) synthesis|
|C||Inhibiting prolactin release|
|D||Stimulating ovarian estrogen and progestin synthesis|
a. Primary amenorrhea is associated with hyperprolactinemia.
b. Women who are amenorrheic from hyperprolactinemia also often present with galactorrhea and infertility Bromocriptine, a dopamine receptor agonist, inhibits prolactin release.
c. The site of action is the pituitary and it involves the same site and mechanism by which dopamine, released from the hypothalamus, normally suppresses prolactin release.
d. Causes of hyperprolactinemia, in both men and women, include pituitary cancer, hypothalamic dysfunction, and some drugs (e.g., antipsychotics, estrogens).