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Dermatology

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STD

Question
4 out of 42
 

What is the most specific test for syphilis? (AIPG 2010)


A VDRL
B RPR

C FTA-Abs
D Kahn’s test

Ans. C

FTA-Abs

1. Specific (Treponemal) Tests

a. Treponemal enzyme immunoassay (EIA) to detect IgG,IgG and IgM or IgM.

b. Treponema pallidum haemagglutination assay (TPHA),

c. Treponema pallidum particle agglutination assay (TPPA).

d. Fluorescent treponemal antibody absorption test (FTA-ABS)

2. Request EIA for anti-treponemal IgM if primary syphilis is suspected IgM is detectable towards the end of the second week of infection while IgG is detectable usually in the fourth or fifth week.

3. The majority of patients who have reactive treponemal tests will have reactive tests for the remainder of their lives, regard-less of treatment or disease activity.

4. However, 15%-25% of patients treated during the primary stage revert to being serologically nonreactive after 2-3 years


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