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Physiology

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Kidney

Question
2 out of 7
 

What is true? (AIIMS NOV 2008)



A Clearance of a substance which is freely filtered and actively secreted is greater than GFR

B Clearance of a substance which is filtered and

C reabsorbed is greater than the clearance of inulin

D Descending loop of Henle has hypotonic fluid

E Descending loop of Henle is permeable to solutes

Ans. A Clearance of a substance which is freely filtered and actively secreted is greater than GFR

I. The explanation is based on the basic definition and the concept of clearance.

II. The clearance of a substance which is freely filtered and neither secreted nor reabsorbed (e.g. inulin clearance) gives the value of GFR.

III. Any substance which has a clearance greater than that of inulin must be getting secreted in addition to being freely filtered.

IV. One of the most important aspects of counter-current multiplier system is the differential permeability characteristic of descending thin segment (DTS) and the ascending thin segment of the loop of Henle (ATS):

a. DTS : is permeable to water but not sodium

b. ATS : is permeable to sodium but not water

V. Due to this, the tubular fluid in the descending loop gets hypertonic whereas in the ascending limb, the tubular fluid becomes dilute.

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