Which antibodies are present in Sjögren’s syndrome? (PNQ)
|D||None of the above|
a. The presence of autoantibodies to Ro/SS – A and La/SS – B antigens in Sjögren’s syndrome is associated with earlier disease onset, longer disease duration, salivary gland enlargement, severity of lymphocytic infiltration of minor salivary glands, and certain extraglandular manifestations such as lymphadenopathy, purpura, and vasculitis.
b. Antibodies to α - fodrin (120kDa), a salivary gland- specific protein may be present.
Manifestations of primary Sjögren’s syndrome (extraglandular features) are:
i. Arthralgia / arthritis v. Raynaud's phenomenon ix. Lymphadenopathy
ii. Lung involvement vi. Vasculitis x. Kidney involvement
iii. Liver involvement vii. Lymphoma xi. Splenomegaly
iv. Peripheral neuropathy viii. Myositis
Extra Edge: Non Hodgkin lymphoma & RTA are very common to occur in Sjögren syndrome (FAQ)