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Medicine

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Rheumatology

Question
6 out of 10
 

Which antibodies are present in Sjögren’s syndrome? (PNQ)



A Alpha fodrin
B Anti centromere

C Anti CCP
D None of the above

Ans. A Alpha fodrin

Extra Edge:

a. The presence of autoantibodies to Ro/SS – A and La/SS – B antigens in Sjögren’s syndrome is associated with earlier disease onset, longer disease duration, salivary gland enlargement, severity of lymphocytic infiltration of minor salivary glands, and certain extraglandular manifestations such as lymphadenopathy, purpura, and vasculitis.

b. Antibodies to α - fodrin (120kDa), a salivary gland- specific protein may be present.

Manifestations of primary Sjögren’s syndrome (extraglandular features) are:

i. Arthralgia / arthritis v. Raynaud's phenomenon ix. Lymphadenopathy

ii. Lung involvement vi. Vasculitis x. Kidney involvement

iii. Liver involvement vii. Lymphoma xi. Splenomegaly

iv. Peripheral neuropathy viii. Myositis

Extra Edge: Non Hodgkin lymphoma & RTA are very common to occur in Sjögren syndrome (FAQ)

Rheumatology Flashcard List

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