Which antitumor drug is not an alkylating agent?
a. Mech. of action of alkylating agents: These agents form reactive intermediates that covalently modify bases in DNA. In addition they can activate apoptosis.
b. Common toxicities: Myelosuppression, alopecia, gonadal dysfunction, pulmonary fibrosis, mucositis.
5-FU is an antimetabolite.