Which cephalosporins can be used in ↓GFR
Cefoperazone is almost totally eliminated by bile. Therefore, it could be used in case of reduced GFR. Ceftrixone too can be used, but has partial elimination by bile. Hence, if we are to choose one option between these, we shall choose cefoperazone (BG Katzung’ 10th Edition, pp-738). Cefoperazone is one of the drug of choice for pseudomonas infection.