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Medicine

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Neurology

Question
13 out of 14
 

Which drug is used for treatment of primary brain cancer? (PNQ)



A Thalidomide
B Temozolomide

C Methotrexate
D None

Ans. B

Temozolomide

Recent Advances:

Chemotherapy for brain Tumour

1). Carmustine (CCNS) lomustine (BCNS)

2). Temozolomide: Its main indication is anaplastic astrocytoma which is refractory to conventional treatment.

(Ref. Hari-18th ed., pg 701)

3). Efaproxiral results in a shift of the hemoglobin oxygen dissociation curve to the right. Therefore, oxygen is more readily released from hemoglobin into tissues. Efaproxiral has significant survival benefit when used as a radiation enhancer in patients with brain metastases originating from breast cancer. It is new drug. It is not given in Harison’s 18th Edition.

Table 374-1 Hereditary Syndromes Associated with Brain Tumors (Ref. Hari-18th ed., Pg 3384, table 379.2)

Syndrome

Nervous System Neoplasms

Neurofibromatosis type 1 (von Recklinghausen's Disease)

Neuroma, schwannoma, meningioma, optic glioma

Neurofibromatosis type 2

Schwannoma, glioma, ependymoma, meningioma

Tuberous sclerosis

Astrocytoma

von Hippel-Lindau

Hemangioblastoma of retina, cerebellum and spinal cord; pheochromocytoma

Li-Fraumeni

Malignant glioma

Turcot

Medulloblastoma, malignant glioma

Gorlin (basal cell nevus syndrome)

Medulloblastoma

Multiple endocrine neoplasia 1 (Werner syndrome)

Pituitary adenoma, malignant schwannoma

Neurology Flashcard List

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