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Physiology

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Blood

Question
38 out of 42
 

Which is Vitamin K dependent clotting factor? (AIIMS NOV 2010)


A Factor VII
B Factor I

C Factor XI
D Factor XII

Ans. A Factor VII

Vitamin K is involved in the carboxylation of certain glutamate residues in proteins to form gamma-carboxyglutamate residues (abbreviated Gla-residues). It play key roles in the regulation of three physiological processes:

  1. Blood coagulation: (prothrombin (factor II), factors VII, IX, X, protein C, protein S, and protein Z
  2. Bone metabolism: osteocalcin, also called bone Gla-protein (BGP), and matrix gla protein (MGP).
  3. Vascular functions.

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