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Pathology

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Immunopathology

Question
4 out of 9
 

Which is an example of Type IV hypersensitivity: (AIIMS Nov 2012)



A Arthrus reaction
B Serum sickness

C Schwartzman reaction
D Granulomatous reaction

Ans. D Granulomatous reaction

Mechanism of Immunologic Tissue injury

Type I (Anaphylactic type)

Formation of IgE

Antibody and release of vasoactive amines

Anaphylaxis, asthma

Type II

(Cytotoxic type)

Formation of IgG, IgM lysis of target cell by C8, 9 fraction of activated complement or antibody dependent cellular cytotoxicity

Autoimmune hemolytic anemia; erythroblastosis foetalis; Goodpasture syndrome, bullous pemphigoid, pernicious anemia acute rheumatic fever

Type III

(Immune complex ds)

Antigen antibody complexes release of lysosomal enzymes and toxic metabolites

Arthus reaction, serum sickness, SLE, acute GN

Type IV (Cell

mediated delayed

Hypersensitivity)

Sensitized T lymphocytes T cell mediated cytotoxicity

Tuberculosis, contact dermatitis transplant rejection

Immunopathology Flashcard List

9 flashcards
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