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Pharmacology

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Blood

Question
42 out of 45
 

Which is not an alkylating agent? (LQ)


A 5-FU
B Melphalan

C Cyclophosphamide
D Chlorambucil

Ans. A 5-FU
Classifications

A. Drugs acting directly on cells (Cytotoxic drugs)

1. Alkylating agents Mechlorethamine

1.Nitrogen mustards (Mustine HCI) Cyclophosphamide, Ifosfamide, Chlorambucil, Melphalan

2. Ethylenimine Thio-TEPA

3. Alkyl sulfonate Busulfan

4. Nitrosoureas Carmustine (BCNU), Lomustine (CCNU)

5. Triazine Dacarbazine (DTIC)

2. Antimetabolites

1.Folate antagonist Methotrexate (Mtx)

2. Purine 6 – Mercaptopurine (6-MP),

antagonist 6 – Thioguanine (6-TG),

Azathioprine, Fludarabine

3. Pyrimidine 5 – Fluorouracil (5-FU),

Antagonist Cytarabine (cytosine arabinoside)

4. Vinca alkaloids Vincristine , Vinblastine

5. Taxanes Paclitaxel, Docetaxel

6. Epipodophyllotoxin Etoposide

7. Camptothecin analogues Topotecan, Irinotecan

8. Antibiotics Actinomycin D (Dactinomycin)

Doxorubicin Daunorubicin (Rubidomycin)

Mitoxantrone Bleomycins, Mitomycin C

9. Miscellaneous Hydroxyurea, Procarbazine, L-Asparaginase,

Cisplatin Carboplatin Imatinib

B. Drugs altering hormonal milieu

1. Glucocorticoids Prednisolone and others

2. Estrogens Fosfestrol, Ethinylestradiol

3. Selective estrogen Tamoxifen, Toremifene

receptor modulators

4. Selective estrogen Fulvestrant

receptor down regulators

5. Aromatase inhibitors Letrozole, Anastrozole, Exemestane

6. Antiandrogen Flutamide, Bicalutamide

7. 5-α reductase inhibitor Finasteride, Dutasteride

8. GnRH analogues Nafarelin, Triptorelin

9. Progestins Hydroxyprogesterone acetate, etC.

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