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Biochemistry

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Lipid

Question
54 out of 63
 

Which is not seen in starvation



A Ketoacidosis

B Hypoglycemia

C Hypercholesterolemia

D Hypertriglyceridemia

Ans. B Hypoglycemia + C. Hypercholesterolemia

a. DM and starvation has similar metabolic profile.

b. In starvation and DM Insulin deficiency and glucagon excess leads to gluconeogenesis, - Glycolysis and oxidation of pyruvate, all maintain blood glucose.

c. In initial fasting - glucose is derived from glycogen.

d. If starvation prolonged →↑ Lipolysis of fat →↑FFAand their oxidation and glucose is synthesized from glycerol fat, then glucose is synthesized from protein.

e. ed oxidation of FFA and their product ketone bodies sparing the non obligatory oxidation of glucose maintain blood glucose level

f. In prolonged starvation body adapt, to use ketone and FFA as source of energy sparing the glucose i.e. in prolonged starvation, glucose contributes less than 5% of total substrates oxidized in the whole body Further maintain blood glucose

g. Glucagon /insulin Ratio Activate Hormone sensitive Lipase →↑FFA→↑oxidation of FFA or

esterificationKetogenesis and Hyper-triglyceridemia.

h. Cholesterol synthesis the major regulatory enzyme is HMG-CoA reductase Activity is ed by ed Insulin and ed glucagon level. But in starvation and DM the condition is reverse i.e. ed Insulin and ed glucagon, therefore, ed cholesterol synthesis and therefore no Hypercholesterolemia

i. So, in starvation counter regulatory mechanisms maintain glucose level in blood.

j. But, if you have to select on answer, select - Hypercholesterolemia

Lipid Flashcard List

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