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Pharmacology

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Analgesics

Question
29 out of 33
 

Which is not used for prophylaxis of migraine



A Sumatriptan

B Valproate

C Propranolol

D Topiramate

Ans. A Sumatriptan

Table :Preventive Treatments in Migraine

Drug

Dose

Selected Side Effects

1. Pizotifen

0.5–2 mg qd

Weight gain

Drowsiness

2. Beta blocker

3. Propranolol

40–120 mg bid

Reduced energy

Tiredness

Postural symptoms

Contraindicated in asthma

4. Tricyclics

5. Amitriptyline

10–75 mg at night

Drowsiness

6. Dothiepin

25–75 mg at night

7. Nortriptyline

25–75 mg at night

Note: Some patients may only need a total dose of 10 mg, although generally 1–1.5 mg/kg body weight is required

8. Anticonvulsants

9. Topiramate

25–200 mg/d

Paresthesias

Cognitive symptoms

Weight loss

Glaucoma

Caution with nephrolithiasis

10. Valproate

400–600 mg bid

Drowsiness

Weight gain

Tremor

Hair loss

Fetal abnormalities

Hematologic or liver abnormalities

11. Gabapentin

900–3600 mg qd

Dizziness

Sedation

12. Serotonergic drugs

13. Methysergide

1–4 mg qd

Drowsiness

Leg cramps

Hair loss

Retroperitoneal fibrosis (1-month drug holiday is required every 6 months)

14. Flunarizineb

5–15 mg qd

Drowsiness

Weight gain

Depression

Parkinsonism

  1. Verapamil
  1. Nimodipine
  1. Clonidine
  1. SSRIs: fluoxetine

(Remember: “triptans” are used to abort acute attack of migraine)

Analgesics Flashcard List

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