Which is true about octreotide? (LQ)
|A||Stimulates growth hormone secretion|
|B||Used in secretory diarrhea|
|D||Contraindicated in acromegaly|
Used in secretory diarrhea
1). Octreotide is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone.
2). It is used in the treatment of (a). acromegaly (b). diarrhea and (c). flushing episodes associated with carcinoid syndrome, and diarrhea in patients with vasoactive intestinal peptide-secreting tumors (VIPomas).
Since octreotide resembles somatostatin in physiological activities, it can:
1). Inhibit secretion of many hormones, such as gastrin, cholecystokinin, glucagon, growth hormone, insulin, secretin, pancreatic polypeptide, TSH, and vasoactive intestinal peptide,
2). Reduce secretion of fluids by the intestine and pancreas,
3). Reduce gastrointestinal motility and inhibit contraction of the gallbladder,
4). Inhibit the action of certain hormones from the anterior pituitary,
5). Cause vasoconstriction in the blood vessels, and
6). Reduce portal vessel pressures in bleeding varices.
1). Octreotide has also been used off-label for the treatment of severe, refractory diarrhea from other causes.
2). It is used in toxicology for the treatment of prolonged recurrent hypoglycemia after sulfonylurea.
3). It has also been used with varying degrees of success in infants with nesidioblastosis to help decrease insulin hypersecretion. (H-18th ed. Pg- 3008)
4). In patients with suspected esophageal varices, octreotide can be given to help decrease bleeding
5). It is used in the treatment of acromegaly. (Ref. Hari-18thed., Pg 2896)