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Neurology

Question
10 out of 18
 

Which is used in treatment of parkinsonism? PNQ



A Clozapine
B Olanzapine

C Risperidone
D All of the above

Ans. D

All of the above

Treatment of Parkinsonism (Ref. Hari-18th ed., pg- 3321)

1). MAO-B inhibitor

a. Selegiline

b. Rasagiline

c. Lazabemide

2). Central Anticholinergic: Benztropine, Biperiden, Orphenadrine, Procyclidine, Trihexyphenidyl.

3). [Trihexyphenidyl: Most commonly used drug, benztropine is the DOC for drug induced parkinsonism]

4). Dopamine agonist

a. Levodopa

b. Amantadine

c. Non ergot alkaloid: Pramipexole, Ropinirole, Rotigotine

d. Ergot alkaloid: Pergolide, Cabergoline, Bromocriptine

5). COMT inhibitor: Tolcapone, Entacapone

6). Atypical antipsychotic, clozapine, olanzapine, risperidone, quetiapine

7). Continuous infusion by levodopa.

Recent Advances:

8). High frequency stimulation of selected area - Subthalamus nuclei or globus pallidus improve symptoms.

9). Surgery

a. Stereotactic thalamotomy and pallidotomy

b. Transplantation of fetal midbrain dopaminergic cells into putamen of pt.

c. Transplantation of autologous adrenal medullary tissue.

Recent Advances:

Newer Drugs in the treatment of Parkinson: Lazabemide, Pramipexole, Ropinirole, Rotigotine, Pergolide, Cabergoline, Tolcapone, Entacapone, clozapine, olanzapine, risperidone, quetiapine

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